reviewTop 1% cited
Clinical use of current polygenic risk scores may exacerbate health disparities
Nature Genetics · 2019 · Vol. 51(4) · pp. 584–591
Alicia R. Martin✉(Broad Institute)Masahiro Kanai(Broad Institute)Yoichiro Kamatani(Kyoto University)Yukinori Okada(RIKEN Center for Integrative Medical Sciences)Benjamin M. Neale(Broad Institute)Mark J. Daly(Broad Institute)
Genetic Associations and EpidemiologyBRCA gene mutations in cancerGenomic variations and chromosomal abnormalitiesPolygenic risk scoreBiologyMultifactorial InheritancePrecision medicineGenome-wide association studyHealth equityDiversity (politics)MedicineGeneticsPublic health
MeSH terms
GenotypeHumansRisk FactorsGenetic Predisposition to DiseaseMultifactorial InheritanceWhite PeopleHealthcare DisparitiesGenome-Wide Association StudyPrecision Medicine
Funding
- Japan Agency for Medical Research and Development
- Masason Foundation
- National Institutes of Health
Citations
2,803
FWCI
231.63
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79
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100%
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References
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A global reference for human genetic variation
Nature · 2015 · 19,538 citations
Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores
The American Journal of Human Genetics · 2015 · 1,472 citations
A reference panel of 64,976 haplotypes for genotype imputation
Nature Genetics · 2016 · 3,228 citations
Human Demographic History Impacts Genetic Risk Prediction across Diverse Populations
The American Journal of Human Genetics · 2017 · 1,539 citations
Comparison of Sociodemographic and Health-Related Characteristics of UK Biobank Participants With Those of the General Population
American Journal of Epidemiology · 2017 · 4,086 citations
The personal and clinical utility of polygenic risk scores
Nature Reviews Genetics · 2018 · 1,681 citations
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