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Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation

Nature Cell Biology · 2018 · Vol. 20(3) · pp. 285–295

Huilin Huang✉(City of Hope)Hengyou Weng(City of Hope)Wenju Sun(Sun Yat-sen University)Xi Qin(City of Hope)Hailing Shi(Howard Hughes Medical Institute)Huizhe Wu(City of Hope)Boxuan Zhao(Howard Hughes Medical Institute)Ana Mesquita(University of Cincinnati Medical Center)Chang Liu(Howard Hughes Medical Institute)Celvie L. Yuan(Cincinnati Children's Hospital Medical Center)Yueh‐Chiang Hu(Cincinnati Children's Hospital Medical Center)Stefan Hüttelmaier(Martin Luther University Halle-Wittenberg)Jennifer R. Skibbe(University of Cincinnati Medical Center)Rui Su(City of Hope)Xiaolan Deng(City of Hope)Lei Dong(City of Hope)Miao Sun(Cincinnati Children's Hospital Medical Center)Chenying Li(City of Hope)Sigrid Nachtergaele(Howard Hughes Medical Institute)Yungui Wang(First Affiliated Hospital Zhejiang University)Chao Hu(First Affiliated Hospital Zhejiang University)Kyle Ferchen(University of Cincinnati Medical Center)Kenneth D. Greis(University of Cincinnati Medical Center)Xi Jiang(City of Hope)Minjie Wei(China Medical University)Liang‐Hu Qu(Sun Yat-sen University)Jun‐Lin Guan(University of Cincinnati Medical Center)Chuan He(Howard Hughes Medical Institute)Jianhua Yang(Sun Yat-sen University)Jianjun Chen(City of Hope)

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RNA modifications and cancer RNA Research and Splicing RNA and protein synthesis mechanismsN6-MethyladenosineMessenger RNARNA-binding proteinTranslation (biology)BiologyP-bodiesCell biologyRNAStress granuleTranslational regulation

MeSH terms

AdenosineBinding SitesCell MovementUterine Cervical NeoplasmsFemaleFetal BloodHeLa CellsHematopoietic Stem CellsHumansLiver NeoplasmsNeoplasm InvasivenessProtein BindingRNA Processing, Post-TranscriptionalRNA, MessengerProtein Biosynthesis