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Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

Molecular Cell · 2010 · Vol. 38(4) · pp. 576–589

Sven Heinz(University of California San Diego)Christopher Benner(University of California San Diego)Nathanael J. Spann(University of California San Diego)Eric Bertolino(University of Chicago)Yin C. Lin(University of California San Diego)Peter Laslo(University of Leeds)Jason X. Cheng(University of Chicago)Cornelis Murre(University of California San Diego)Harinder Singh(University of Chicago)Christopher K. Glass✉(University of California San Diego)

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Immune Cell Function and Interaction Epigenetics and DNA Methylation T-cell and B-cell ImmunologyBiologyTranscription factorCell typeGeneticsDNA binding siteCell biologyCellGeneComputational biologyPromoter

MeSH terms

Proto-Oncogene Protein Spi-1AnimalsB-LymphocytesBinding SitesMacrophagesMaleMice, Inbred C57BLProto-Oncogene ProteinsTranscription FactorsTrans-ActivatorsCell LineageOligonucleotide Array Sequence AnalysisRegulatory Elements, TranscriptionalMice

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