reviewTop 1% cited
Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing
Nature Immunology · 2016 · Vol. 17(10) · pp. 1142–1149
Qi Chen✉(Fujian Normal University)Lijun Sun(The University of Texas Southwestern Medical Center)Zhijian J. Chen(The University of Texas Southwestern Medical Center)
interferon and immune responsesViral Infections and VectorsMosquito-borne diseases and controlStingInnate immune systemCell biologyBiologySignal transductionImmune systemStimulator of interferon genesDNAImmunitySignal transducing adaptor protein
MeSH terms
STING ProteinCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseCyclic AMPAnimalsCytosolDNAHumansImmunity, InnateImmunologic SurveillanceInfectionsInflammationMembrane ProteinsNeoplasmsNucleotidyltransferasesSignal Transduction
Citations
2,154
FWCI
61.87
field-weighted impact
References
107
Percentile
100%
vs. same field & year
Citations per year
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References
Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity
Cell Reports · 2015 · 1,453 citations
STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors
Immunity · 2014 · 2,009 citations
The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation
Immunity · 2008 · 1,469 citations
The Innate Immune DNA Sensor cGAS Produces a Noncanonical Cyclic Dinucleotide that Activates Human STING
Cell Reports · 2013 · 739 citations
STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors
Immunity · 2014 · 1,776 citations
IKKε and TBK1 are essential components of the IRF3 signaling pathway
Nature Immunology · 2003 · 2,672 citations
Deregulation of STING Signaling in Colorectal Carcinoma Constrains DNA Damage Responses and Correlates With Tumorigenesis
Cell Reports · 2015 · 568 citations
Inflammasomes: mechanism of assembly, regulation and signalling
Nature reviews. Immunology · 2016 · 3,348 citations
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