articleTop 1% cited
IKKε and TBK1 are essential components of the IRF3 signaling pathway
Nature Immunology · 2003 · Vol. 4(5) · pp. 491–496
Katherine A. Fitzgerald✉Sarah M. McWhirter(Harvard University)L. Kerrie(Millennium Engineering and Integration (United States))Daniel C. Rowe(University of Massachusetts Chan Medical School)Eicke Latz(University of Massachusetts Chan Medical School)Douglas T. Golenbock(University of Massachusetts Chan Medical School)Anthony J. Coyle(Millennium Engineering and Integration (United States))Sha-Mei Liao(Millennium Engineering and Integration (United States))Tom Maniatis(Harvard University)
NF-κB Signaling Pathwaysinterferon and immune responsesImmune Response and InflammationIRF3TANK-binding kinase 1Interferon regulatory factorsIκB kinaseSignal transductionInnate immune systemKinaseCell biologyTranscription factorPhosphorylation
MeSH terms
DNA-Binding ProteinsGene Expression RegulationHumansImmunity, InnateMembrane GlycoproteinsReceptors, Cell SurfaceTranscription FactorsVirus DiseasesSignal TransductionNF-kappa BInterferon-betaProtein Serine-Threonine KinasesChemokine CCL5Drosophila ProteinsAdaptor Proteins, Vesicular Transport
Citations
2,672
FWCI
53.98
field-weighted impact
References
45
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100%
vs. same field & year
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References
Lipopolysaccharide Stimulates the MyD88-Independent Pathway and Results in Activation of IFN-Regulatory Factor 3 and the Expression of a Subset of Lipopolysaccharide-Inducible Genes
The Journal of Immunology · 2001 · 1,088 citations
Virus-Dependent Phosphorylation of the IRF-3 Transcription Factor Regulates Nuclear Translocation, Transactivation Potential, and Proteasome-Mediated Degradation
Molecular and Cellular Biology · 1998 · 914 citations
Innate Immune Recognition
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IKKε and TBK1 are essential components of the IRF3 signaling pathway
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