article Open AccessTop 1% cited
STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors
Immunity · 2014 · Vol. 41(5) · pp. 830–842
Seng‐Ryong Woo✉(University of Chicago)Mercedes B. Fuertes(University of Chicago)Leticia Corrales(University of Chicago)Stefani Spranger(University of Chicago)Michael J. Furdyna(University of Chicago)Michael Y.K. Leung(University of Chicago)Ryan Duggan(University of Chicago)Ying Wang(University of Chicago)Glen N. Barber(University of Miami)Katherine A. Fitzgerald(University of Massachusetts Chan Medical School)Maria-Luisa Alegre(University of Chicago)Thomas F. Gajewski(University of Chicago)
interferon and immune responsesViral Infections and VectorsInflammasome and immune disordersInnate immune systemBiologyStingImmune systemDNACytosolCell biologyImmunityImmune recognitionCancer research
MeSH terms
STING ProteinCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseAnimalsAntigen-Presenting CellsDendritic CellsDNAImmunity, InnateLymphocyte ActivationMelanoma, ExperimentalMembrane ProteinsMice, Inbred C57BLNucleotidyltransferasesReceptors, Antigen, T-CellInterferon-betaMice, Knockout
Citations
1,776
FWCI
31.97
field-weighted impact
References
54
Percentile
100%
vs. same field & year
Citations per year
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References
Calreticulin exposure dictates the immunogenicity of cancer cell death
Nature Medicine · 2006 · 3,040 citations
Prognostic significance of tumor-infiltrating T cells in ovarian cancer: A meta-analysis
Gynecologic Oncology · 2011 · 677 citations
Toll-like receptor 4–dependent contribution of the immune system to anticancer chemotherapy and radiotherapy
Nature Medicine · 2007 · 2,933 citations
Immunogenic Cell Death in Cancer Therapy
Annual Review of Immunology · 2012 · 3,154 citations
IFI16 is an innate immune sensor for intracellular DNA
Nature Immunology · 2010 · 1,616 citations
Up-Regulation of PD-L1, IDO, and T <sub>regs</sub> in the Melanoma Tumor Microenvironment Is Driven by CD8 <sup>+</sup> T Cells
Science Translational Medicine · 2013 · 1,662 citations
Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer
New England Journal of Medicine · 2012 · 12,531 citations
Chemokine Expression in Melanoma Metastases Associated with CD8+ T-Cell Recruitment
Cancer Research · 2009 · 1,114 citations
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