review Open AccessTop 1% cited
Lag-3, Tim-3, and TIGIT: Co-inhibitory Receptors with Specialized Functions in Immune Regulation
Immunity · 2016 · Vol. 44(5) · pp. 989–1004
Ana C. Anderson✉(Brigham and Women's Hospital)Nicole Joller(University of Zurich)Vijay K. Kuchroo(Brigham and Women's Hospital)
Galectins and Cancer BiologyImmune Cell Function and InteractionToxin Mechanisms and ImmunotoxinsTIGITReceptorBiologyImmune receptorInhibitory postsynaptic potentialImmune systemEffectorCell biologyImmunologyT cell
MeSH terms
Hepatitis A Virus Cellular Receptor 2Lymphocyte Activation Gene 3 ProteinAnimalsHumansImmune ToleranceLymphocyte ActivationReceptors, ImmunologicT-LymphocytesSignal TransductionAntigens, CDReceptor Cross-TalkCTLA-4 AntigenProgrammed Cell Death 1 Receptor
Funding
- National Institutes of Health
Citations
2,113
FWCI
69.33
field-weighted impact
References
135
Percentile
100%
vs. same field & year
Citations per year
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References
Molecular and cellular insights into T cell exhaustion
Nature reviews. Immunology · 2015 · 4,348 citations
Binding of the Fap2 Protein of Fusobacterium nucleatum to Human Inhibitory Receptor TIGIT Protects Tumors from Immune Cell Attack
Immunity · 2015 · 1,371 citations
Myeloid-derived suppressor cells as regulators of the immune system
Nature reviews. Immunology · 2009 · 6,584 citations
The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells
Nature Immunology · 2008 · 1,435 citations
Development of Lupus-like Autoimmune Diseases by Disruption of the PD-1 Gene Encoding an ITIM Motif-Carrying Immunoreceptor
Immunity · 1999 · 2,706 citations
The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity
Nature Immunology · 2005 · 2,002 citations
Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
Immunity · 1995 · 2,880 citations
Improved Survival with Ipilimumab in Patients with Metastatic Melanoma
New England Journal of Medicine · 2010 · 15,037 citations
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Lag-3, Tim-3, and TIGIT: Co-inhibitory Receptors with Specialized Functions in Immune Regulation
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