articleTop 10% cited
The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells
Nature Immunology · 2008 · Vol. 10(1) · pp. 48–57
Xin Yu✉Kristin Harden(PDL BioPharma (United States))Lino C. Gonzalez(PDL BioPharma (United States))Michelle Francesco(Gene Therapy Laboratory)Eugene Y. Chiang(Gene Therapy Laboratory)Bryan Irving(Gene Therapy Laboratory)Irene Tom(PDL BioPharma (United States))Sinisa Ivelja(Gene Therapy Laboratory)Canio J. Refino(Gene Therapy Laboratory)Hilary Clark(Bioinformatics Institute)Dan Eaton(PDL BioPharma (United States))Jane L. Grogan(Gene Therapy Laboratory)
Immune Cell Function and InteractionT-cell and B-cell ImmunologyImmunotherapy and Immune ResponsesTIGITCell biologyDendritic cellBiologyMolecular biologyT cellChemistryImmune systemImmunology
MeSH terms
Amino Acid SequenceAnimalsCell CommunicationCell DifferentiationCells, CulturedCricetulusDendritic CellsCricetinaeHumansImmune ToleranceImmunologic MemoryMembrane ProteinsMice, Inbred C57BLMolecular Sequence DataProtein Binding
Funding
- Genentech
Citations
1,435
FWCI
4.00
field-weighted impact
References
50
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94%
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References
Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells
Nature Immunology · 2010 · 5,839 citations
CD4+CD25+ Immunoregulatory T Cells
Immunity · 2002 · 1,397 citations
Control of Regulatory T Cell Development by the Transcription Factor <i>Foxp3</i>
Science · 2003 · 8,062 citations
Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self-tolerance
Nature Immunology · 2002 · 1,718 citations
Regulatory T Cell Lineage Specification by the Forkhead Transcription Factor Foxp3
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Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4
The Journal of Experimental Medicine · 2000 · 2,205 citations
Cytotoxic T Lymphocyte–Associated Antigen 4 Plays an Essential Role in the Function of Cd25+Cd4+ Regulatory Cells That Control Intestinal Inflammation
The Journal of Experimental Medicine · 2000 · 2,174 citations
Modulation of tryptophan catabolism by regulatory T cells
Nature Immunology · 2003 · 1,330 citations
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