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Binding of the Fap2 Protein of Fusobacterium nucleatum to Human Inhibitory Receptor TIGIT Protects Tumors from Immune Cell Attack

Immunity · 2015 · Vol. 42(2) · pp. 344–355

Chamutal Gur✉(Hebrew University of Jerusalem)Yara Ibrahim(Hebrew University of Jerusalem)Batya Isaacson(Hebrew University of Jerusalem)Rachel Yamin(Hebrew University of Jerusalem)Jawad Abed(Hebrew University of Jerusalem)Moriya Gamliel(Hebrew University of Jerusalem)Jonatan Enk(Hebrew University of Jerusalem)Yotam Bar‐On(Hebrew University of Jerusalem)Noah Stanietsky-Kaynan(Hebrew University of Jerusalem)Shunit Coppenhagen‐Glazer(Hebrew University of Jerusalem)Noam Shussman(Hadassah Medical Center)Gideon Almogy(Hadassah Medical Center)Angélica Cuapio(Medical University of Vienna)Erhard Hofer(Medical University of Vienna)Dror Mevorach(Hebrew University of Jerusalem)Adi Tabib(Hebrew University of Jerusalem)Rona Ortenberg(Sheba Medical Center)Gal Markel(Sheba Medical Center)Karmela Miklić(University of Rijeka)Stipan Jonjić(University of Rijeka)Caitlin A. Brennan(Harvard University)Wendy S. Garrett(Harvard University)Gilad Bachrach(Hebrew University of Jerusalem)Ofer Mandelboim(Hebrew University of Jerusalem)

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Immune Cell Function and Interaction Immune cells in cancer Gut microbiota and healthTIGITFusobacterium nucleatumImmune systemBiologyCellCancer researchMicrobiologyReceptorImmunologyT cell

MeSH terms

AdenocarcinomaAnimalsBacterial Outer Membrane ProteinsCell LineColonic NeoplasmsHumansKiller Cells, NaturalProtein BindingReceptors, ImmunologicLymphocytes, Tumor-InfiltratingFusobacterium nucleatumTumor EscapeCell ProliferationMiceTumor Microenvironment

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