article Open AccessTop 1% cited
Rare-Variant Association Testing for Sequencing Data with the Sequence Kernel Association Test
The American Journal of Human Genetics · 2011 · Vol. 89(1) · pp. 82–93
Michael C. Wu(University of North Carolina at Chapel Hill)Seunggeun Lee(Harvard University)Tianxi Cai(Harvard University)Yun Li(University of North Carolina at Chapel Hill)Michael Boehnke(University of Michigan–Ann Arbor)Xihong Lin✉(Harvard University)
Genetic Associations and EpidemiologyGenomics and Rare DiseasesGenomic variations and chromosomal abnormalitiesGenetic associationAssociation testCovariateGenome-wide association studyType I and type II errorsWhole genome sequencingBiologyComputational biologyGeneticsData mining
MeSH terms
Computer SimulationGene FrequencyHumansModels, GeneticSoftwareGenetic VariationSequence AnalysisDatabases, GeneticGenetic LociGenetic Association Studies
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PLoS Genetics · 2009 · 1,166 citations
Methods for Detecting Associations with Rare Variants for Common Diseases: Application to Analysis of Sequence Data
The American Journal of Human Genetics · 2008 · 1,605 citations
Pooled Association Tests for Rare Variants in Exon-Resequencing Studies
The American Journal of Human Genetics · 2010 · 772 citations
Mapping short DNA sequencing reads and calling variants using mapping quality scores
Genome Research · 2008 · 2,707 citations
Principal components analysis corrects for stratification in genome-wide association studies
Nature Genetics · 2006 · 10,603 citations
Testing for an Unusual Distribution of Rare Variants
PLoS Genetics · 2011 · 598 citations
Missing heritability and strategies for finding the underlying causes of complex disease
Nature Reviews Genetics · 2010 · 1,747 citations
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