articleTop 1% cited
Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm
Nature Protocols · 2009 · Vol. 4(7) · pp. 1073–1081
P. Naresh Kumar✉(J. Craig Venter Institute)Steven Henikoff(Howard Hughes Medical Institute)Pauline C. Ng(Fred Hutch Cancer Center)
RNA and protein synthesis mechanismsGenomics and Phylogenetic StudiesMachine Learning in BioinformaticsGeneticsScale-invariant feature transformBiologySequence alignmentCoding regionPhenotypeMutationSingle-nucleotide polymorphismComputational biologyGene
MeSH terms
AlgorithmsAmino Acid SequenceComputer SimulationMolecular Sequence DataPhenotypeProteinsSoftwareAmino Acid SubstitutionInternet
Funding
- Menzies School of Health Research
Citations
6,687
FWCI
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References
PANTHER: A Library of Protein Families and Subfamilies Indexed by Function
Genome Research · 2003 · 3,062 citations
SIFT: predicting amino acid changes that affect protein function
Nucleic Acids Research · 2003 · 6,783 citations
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs
Nucleic Acids Research · 1997 · 74,154 citations
Predicting Deleterious Amino Acid Substitutions
Genome Research · 2001 · 2,698 citations
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