article Open AccessTop 1% cited
Methods for Detecting Associations with Rare Variants for Common Diseases: Application to Analysis of Sequence Data
The American Journal of Human Genetics · 2008 · Vol. 83(3) · pp. 311–321
Bingshan Li(Baylor College of Medicine)Suzanne M. Leal✉(Baylor College of Medicine)
Genetic Associations and EpidemiologyGenomics and Rare DiseasesGenomic variations and chromosomal abnormalitiesUnivariateComputational biologyWhole genome sequencing1000 Genomes ProjectBiologyGeneticsGenetic associationSequence (biology)Candidate geneGenome
MeSH terms
Genetic MarkersHaplotypesHumansModels, GeneticGenetic VariationLinkage DisequilibriumGenome, HumanGenetic Predisposition to DiseasePolymorphism, Single Nucleotide
Funding
- National Institutes of Health
Citations
1,605
FWCI
42.70
field-weighted impact
References
42
Percentile
100%
vs. same field & year
Citations per year
Cited by
Missing heritability and strategies for finding the underlying causes of complex disease
Nature Reviews Genetics · 2010 · 1,747 citations
A Groupwise Association Test for Rare Mutations Using a Weighted Sum Statistic
PLoS Genetics · 2009 · 1,166 citations
Rare-Variant Association Testing for Sequencing Data with the Sequence Kernel Association Test
The American Journal of Human Genetics · 2011 · 2,515 citations
Exome sequencing as a tool for Mendelian disease gene discovery
Nature Reviews Genetics · 2011 · 1,675 citations
Testing for an Unusual Distribution of Rare Variants
PLoS Genetics · 2011 · 598 citations
Rare-Variant Association Analysis: Study Designs and Statistical Tests
The American Journal of Human Genetics · 2014 · 1,100 citations
Optimal Unified Approach for Rare-Variant Association Testing with Application to Small-Sample Case-Control Whole-Exome Sequencing Studies
The American Journal of Human Genetics · 2012 · 1,126 citations
Pooled Association Tests for Rare Variants in Exon-Resequencing Studies
The American Journal of Human Genetics · 2010 · 772 citations
References
Statistical Methods for Research Workers
American Journal of Clinical Pathology · 1945 · 11,038 citations
Categorical Data Analysis
Technometrics · 1991 · 9,086 citations
A solution to the problem of separation in logistic regression
Statistics in Medicine · 2002 · 2,082 citations
Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families
Science · 1993 · 9,373 citations
Genome-wide association studies for common diseases and complex traits
Nature Reviews Genetics · 2005 · 2,867 citations
On the allelic spectrum of human disease
Trends in Genetics · 2001 · 1,186 citations
Are Rare Variants Responsible for Susceptibility to Complex Diseases?
The American Journal of Human Genetics · 2001 · 1,223 citations
SIFT: predicting amino acid changes that affect protein function
Nucleic Acids Research · 2003 · 6,783 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.