review Open AccessTop 1% cited
The unfolded protein response: controlling cell fate decisions under ER stress and beyond
Nature Reviews Molecular Cell Biology · 2012 · Vol. 13(2) · pp. 89–102
Claudio Hetz✉(University of Chile)
Endoplasmic Reticulum Stress and DiseaseAutophagy in Disease and TherapyPancreatic function and diabetesUnfolded protein responseATF6Endoplasmic reticulumCell biologyEIF-2 kinaseCrosstalkTranscription factorProtein foldingProtein kinase AKinase
MeSH terms
Adaptation, BiologicalAnimalsCell DifferentiationCell SurvivalHumansCell DeathApoptosisCell ProliferationUnfolded Protein ResponseEndoplasmic Reticulum Stress
Citations
4,068
FWCI
94.76
field-weighted impact
References
132
Percentile
100%
vs. same field & year
Citations per year
Cited by
Radiation-induced immunogenic modulation of tumor enhances antigen processing and calreticulin exposure, resulting in enhanced T-cell killing
Oncotarget · 2013 · 390 citations
Crosstalk of autophagy and apoptosis: Involvement of the dual role of autophagy under ER stress
Journal of Cellular Physiology · 2017 · 523 citations
The C/EBP Homologous Protein (CHOP) Transcription Factor Functions in Endoplasmic Reticulum Stress-Induced Apoptosis and Microbial Infection
Frontiers in Immunology · 2019 · 1,095 citations
UPR, autophagy, and mitochondria crosstalk underlies the ER stress response
Trends in Biochemical Sciences · 2015 · 1,085 citations
ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death
Nature Cell Biology · 2013 · 1,664 citations
Cancer and ER stress: Mutual crosstalk between autophagy, oxidative stress and inflammatory response
Biomedicine & Pharmacotherapy · 2019 · 481 citations
Detection of immunogenic cell death and its relevance for cancer therapy
Cell Death and Disease · 2020 · 1,033 citations
The Unfolded Protein Response and Cell Fate Control
Molecular Cell · 2017 · 1,451 citations
References
Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response
Nature Cell Biology · 2000 · 2,842 citations
ER Stress Regulation of ATF6 Localization by Dissociation of BiP/GRP78 Binding and Unmasking of Golgi Localization Signals
Developmental Cell · 2002 · 1,429 citations
Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress
Nature Cell Biology · 2011 · 2,594 citations
Transcriptional Induction of Mammalian ER Quality Control Proteins Is Mediated by Single or Combined Action of ATF6α and XBP1
Developmental Cell · 2007 · 1,023 citations
Mitochondria and cell death: outer membrane permeabilization and beyond
Nature Reviews Molecular Cell Biology · 2010 · 2,483 citations
Signal integration in the endoplasmic reticulum unfolded protein response
Nature Reviews Molecular Cell Biology · 2007 · 6,243 citations
Feedback Inhibition of the Unfolded Protein Response by <i>GADD34</i>-Mediated Dephosphorylation of eIF2α
The Journal of Cell Biology · 2001 · 1,357 citations
THE MAMMALIAN UNFOLDED PROTEIN RESPONSE
Annual Review of Biochemistry · 2005 · 3,009 citations
Related articles
The unfolded protein response: controlling cell fate decisions under ER stress and beyond
Nature Reviews Molecular Cell Biology · 2012 · 4,068 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.