review Open AccessTop 1% cited
The Unfolded Protein Response and Cell Fate Control
Molecular Cell · 2017 · Vol. 69(2) · pp. 169–181
Claudio Hetz✉(Harvard University)Feroz R. Papa✉(University of California, San Francisco)
Endoplasmic Reticulum Stress and DiseaseRNA regulation and diseaseTransgenic Plants and ApplicationsBiologyUnfolded protein responseCell fate determinationCell biologyComputational biologyCellEvolutionary biologyGeneticsEndoplasmic reticulumTranscription factor
MeSH terms
AnimalsEndoplasmic ReticulumEndoribonucleasesHomeostasisHumansModels, BiologicalSignal TransductionApoptosisProtein Serine-Threonine KinasesProtein FoldingCell LineageeIF-2 KinaseActivating Transcription Factor 6Secretory PathwayUnfolded Protein Response
Funding
- Burroughs Wellcome Fund
- Michael J. Fox Foundation for Parkinson's Research
- Muscular Dystrophy Association
- Leona M. and Harry B. Helmsley Charitable Trust
- Juvenile Diabetes Research Foundation United Kingdom
- European Commission
- Instituto Millenium
- National Institutes of Health
- Comisión Nacional de Investigación Científica y Tecnológica
- Fondo Nacional de Desarrollo Científico y Tecnológico
- Air Force Office of Scientific Research
- Office of Naval Research Global
Citations
1,451
FWCI
53.30
field-weighted impact
References
127
Percentile
100%
vs. same field & year
Citations per year
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References
Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response
Nature Cell Biology · 2000 · 2,842 citations
ER Stress Regulation of ATF6 Localization by Dissociation of BiP/GRP78 Binding and Unmasking of Golgi Localization Signals
Developmental Cell · 2002 · 1,429 citations
Perk Is Essential for Translational Regulation and Cell Survival during the Unfolded Protein Response
Molecular Cell · 2000 · 1,997 citations
Stress-Independent Activation of XBP1s and/or ATF6 Reveals Three Functionally Diverse ER Proteostasis Environments
Cell Reports · 2013 · 575 citations
Transcriptional Induction of Mammalian ER Quality Control Proteins Is Mediated by Single or Combined Action of ATF6α and XBP1
Developmental Cell · 2007 · 1,023 citations
XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response
Molecular and Cellular Biology · 2003 · 2,053 citations
An Integrated Stress Response Regulates Amino Acid Metabolism and Resistance to Oxidative Stress
Molecular Cell · 2003 · 3,274 citations
Mammalian Transcription Factor ATF6 Is Synthesized as a Transmembrane Protein and Activated by Proteolysis in Response to Endoplasmic Reticulum Stress
Molecular Biology of the Cell · 1999 · 2,020 citations
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