reviewTop 1% cited
Signal integration in the endoplasmic reticulum unfolded protein response
Nature Reviews Molecular Cell Biology · 2007 · Vol. 8(7) · pp. 519–529
David Ron✉(New York University)Peter Walter(Howard Hughes Medical Institute)
Endoplasmic Reticulum Stress and DiseaseAutophagy in Disease and TherapyPancreatic function and diabetesUnfolded protein responseEndoplasmic reticulumCell biologySecretory proteinSignal transductionSecretory pathwayBiologyEndoplasmic-reticulum-associated protein degradationIntracellularSecretion
MeSH terms
AnimalsEndoplasmic ReticulumGene Expression RegulationHumansModels, BiologicalSignal TransductionProtein FoldingOxidative Stress
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References
Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response
Nature Cell Biology · 2000 · 2,842 citations
ER Stress Regulation of ATF6 Localization by Dissociation of BiP/GRP78 Binding and Unmasking of Golgi Localization Signals
Developmental Cell · 2002 · 1,429 citations
Perk Is Essential for Translational Regulation and Cell Survival during the Unfolded Protein Response
Molecular Cell · 2000 · 1,997 citations
Autophagy Counterbalances Endoplasmic Reticulum Expansion during the Unfolded Protein Response
PLoS Biology · 2006 · 997 citations
Gadd153 Sensitizes Cells to Endoplasmic Reticulum Stress by Down-Regulating Bcl2 and Perturbing the Cellular Redox State
Molecular and Cellular Biology · 2001 · 1,882 citations
Translational Control Is Required for the Unfolded Protein Response and In Vivo Glucose Homeostasis
Molecular Cell · 2001 · 1,342 citations
CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum
Genes & Development · 1998 · 2,003 citations
Feedback Inhibition of the Unfolded Protein Response by <i>GADD34</i>-Mediated Dephosphorylation of eIF2α
The Journal of Cell Biology · 2001 · 1,357 citations
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