articleTop 1% cited
ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death
Nature Cell Biology · 2013 · Vol. 15(5) · pp. 481–490
Jaeseok Han(Sanford Burnham Prebys Medical Discovery Institute)Sung Hoon Back(Regional West Medical Center)Junguk Hur(University of Michigan–Ann Arbor)Yu-Hsuan Lin(University of Michigan–Ann Arbor)Robert Gildersleeve(Regional West Medical Center)Jixiu Shan(Florida College)Celvie L. Yuan(University School)Dawid Krokowski(Case Western Reserve University)Shiyu Wang(Regional West Medical Center)Maria Hatzoglou(Case Western Reserve University)Michael S. Kilberg(Florida College)Maureen A. Sartor(University of Michigan–Ann Arbor)Randal J. Kaufman✉(Regional West Medical Center)
Endoplasmic Reticulum Stress and DiseaseRNA regulation and diseaseCRISPR and Genetic EngineeringATF4Unfolded protein responseCell biologyEndoplasmic reticulumProtein biosynthesisProgrammed cell deathCHOPBiologyTranscription factorApoptosis
MeSH terms
Adenosine TriphosphateAnimalsBinding SitesCell SurvivalGene Expression RegulationPhosphorylationPromoter Regions, GeneticProtein BindingRNA, MessengerTranscription, GeneticProtein BiosynthesisEukaryotic Initiation Factor-2Cell DeathReactive Oxygen SpeciesProtein Folding
Funding
- University of Michigan
Citations
1,664
FWCI
59.01
field-weighted impact
References
66
Percentile
100%
vs. same field & year
Citations per year
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References
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Molecular and Cellular Biology · 2001 · 1,882 citations
Translational Control Is Required for the Unfolded Protein Response and In Vivo Glucose Homeostasis
Molecular Cell · 2001 · 1,342 citations
CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum
Genes & Development · 1998 · 2,003 citations
Feedback Inhibition of the Unfolded Protein Response by <i>GADD34</i>-Mediated Dephosphorylation of eIF2α
The Journal of Cell Biology · 2001 · 1,357 citations
Regulated Translation Initiation Controls Stress-Induced Gene Expression in Mammalian Cells
Molecular Cell · 2000 · 3,216 citations
An Integrated Stress Response Regulates Amino Acid Metabolism and Resistance to Oxidative Stress
Molecular Cell · 2003 · 3,274 citations
CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum
Genes & Development · 2004 · 1,973 citations
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