article Open AccessTop 1% cited
ER Stress Regulation of ATF6 Localization by Dissociation of BiP/GRP78 Binding and Unmasking of Golgi Localization Signals
Developmental Cell · 2002 · Vol. 3(1) · pp. 99–111
Jingshi Shen✉(Columbia University)Xi Chen(Columbia University)Linda M. Hendershot(St. Jude Children's Research Hospital)Ron Prywes(Columbia University)
Endoplasmic Reticulum Stress and DiseaseAutophagy in Disease and TherapyHeat shock proteins researchGolgi apparatusEndoplasmic reticulumUnfolded protein responseATF6Cell biologyBiologyActivating transcription factorTransmembrane proteinTranscription factorChaperone (clinical)
MeSH terms
Endoplasmic Reticulum Chaperone BiPAnimalsCarrier ProteinsCell CompartmentationDNA-Binding ProteinsEndoplasmic ReticulumEukaryotic CellsGene Expression RegulationGolgi ApparatusHeat-Shock ProteinsHeLa CellsHumansMutationProtein BindingStress, Physiological
Funding
- National Institutes of Health
Citations
1,429
FWCI
14.24
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50
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100%
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References
Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response
Nature Cell Biology · 2000 · 2,842 citations
Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators
Genes & Development · 1998 · 1,904 citations
CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum
Genes & Development · 1998 · 2,003 citations
Intracellular signaling from the endoplasmic reticulum to the nucleus: the unfolded protein response in yeast and mammals
Current Opinion in Cell Biology · 2001 · 769 citations
ER Stress Induces Cleavage of Membrane-Bound ATF6 by the Same Proteases that Process SREBPs
Molecular Cell · 2000 · 1,829 citations
Regulated Translation Initiation Controls Stress-Induced Gene Expression in Mammalian Cells
Molecular Cell · 2000 · 3,216 citations
Mammalian Transcription Factor ATF6 Is Synthesized as a Transmembrane Protein and Activated by Proteolysis in Response to Endoplasmic Reticulum Stress
Molecular Biology of the Cell · 1999 · 2,020 citations
ATF6 Activated by Proteolysis Binds in the Presence of NF-Y (CBF) Directly to the<i>cis</i>-Acting Element Responsible for the Mammalian Unfolded Protein Response
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