reviewTop 1% cited
Hypoxia-Inducible Factor-1 (HIF-1)
Molecular Pharmacology · 2006 · Vol. 70(5) · pp. 1469–1480
Qingdong Ke✉(New York University)Max Costa
Cancer, Hypoxia, and MetabolismUbiquitin and proteasome pathwaysRNA modifications and cancerHydroxylationHypoxia-Inducible Factor 1Ubiquitin ligaseAcetylationHypoxia-inducible factorsProtein subunitUbiquitinOxygen tensionG alpha subunitHIF1A
MeSH terms
AnimalsGene Expression RegulationHumansHypoxia-Inducible Factor 1
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Cited by
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References
Hypoxia — a key regulatory factor in tumour growth
Nature reviews. Cancer · 2002 · 5,147 citations
FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor
Genes & Development · 2002 · 1,520 citations
Targeting HIF-1 for cancer therapy
Nature reviews. Cancer · 2003 · 6,642 citations
HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1 in normoxia
The EMBO Journal · 2003 · 1,329 citations
Cellular adaptation to hypoxia: O <sub>2</sub> ‐sensing protein hydroxylases, hypoxia‐inducible transcription factors, and O <sub>2</sub> ‐regulated gene expression
The FASEB Journal · 2002 · 1,122 citations
The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated Macrophages
American Journal Of Pathology · 2000 · 1,298 citations
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.
Proceedings of the National Academy of Sciences · 1995 · 6,172 citations
Mechanisms of p53-dependent apoptosis
Biochemical Society Transactions · 2001 · 533 citations
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