article Open AccessTop 1% cited
The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated Macrophages
American Journal Of Pathology · 2000 · Vol. 157(2) · pp. 411–421
Katherine Louise Talks✉(University of Oxford)Helen Turley(University of Oxford)Kevin C. Gatter(University of Oxford)Patrick H. Maxwell(Centre for Human Genetics)Christopher W. Pugh(Centre for Human Genetics)Peter J. Ratcliffe(Centre for Human Genetics)Adrian L. Harris(John Radcliffe Hospital)
Cancer, Hypoxia, and MetabolismHigh Altitude and HypoxiaAdipose Tissue and MetabolismHypoxia-inducible factorsHypoxia (environmental)HIF1ACancer researchHypoxia-Inducible Factor 1Distribution (mathematics)BiologyChemistryGeneRegulation of gene expression
MeSH terms
Endothelial PAS Domain-Containing Protein 1AnimalsCell LineDNA-Binding ProteinsHumansImmunohistochemistryMacrophagesNeoplasmsNuclear ProteinsRNA, MessengerTissue DistributionTranscription FactorsTumor Cells, CulturedBlotting, WesternTrans-Activators
Citations
1,298
FWCI
17.85
field-weighted impact
References
53
Percentile
100%
vs. same field & year
Citations per year
Cited by
Inhibitory effect of tumor cell–derived lactic acid on human T cells
Blood · 2007 · 1,838 citations
Regulation of Hypoxia-Inducible Factor 1α Expression and Function by the Mammalian Target of Rapamycin
Molecular and Cellular Biology · 2002 · 1,171 citations
Tumor-Associated Macrophages as Major Players in the Tumor Microenvironment
Cancers · 2014 · 1,562 citations
Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation
Journal of Leukocyte Biology · 2009 · 1,423 citations
Cellular adaptation to hypoxia: O <sub>2</sub> ‐sensing protein hydroxylases, hypoxia‐inducible transcription factors, and O <sub>2</sub> ‐regulated gene expression
The FASEB Journal · 2002 · 1,122 citations
Oxidative stress and oxidative damage in chemical carcinogenesis
Toxicology and Applied Pharmacology · 2011 · 459 citations
Biology of HIF-1α
Cell Death and Differentiation · 2008 · 914 citations
Role of hypoxia in the hallmarks of human cancer
Journal of Cellular Biochemistry · 2009 · 499 citations
References
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.
Proceedings of the National Academy of Sciences · 1995 · 6,172 citations
Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in breast cancer
Human Pathology · 1995 · 620 citations
Cellular and developmental control of O<sub>2</sub> homeostasis by hypoxia-inducible factor 1α
Genes & Development · 1998 · 2,467 citations
HIF-1alpha is required for solid tumor formation and embryonic vascularization
The EMBO Journal · 1998 · 1,593 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.