reviewTop 1% cited
Hypoxia — a key regulatory factor in tumour growth
Nature reviews. Cancer · 2002 · Vol. 2(1) · pp. 38–47
Adrian L. Harris✉(John Radcliffe Hospital)
Cancer, Hypoxia, and MetabolismUbiquitin and proteasome pathwaysATP Synthase and ATPases ResearchHypoxia (environmental)AngiogenesisCancer researchSignalling pathwaysBiologySignal transductionCell biologyChemistry
MeSH terms
Endothelial PAS Domain-Containing Protein 1AnimalsAntineoplastic AgentsCell DivisionCell SurvivalDNA DamageDNA-Binding ProteinsErythropoietinEmbryonic and Fetal DevelopmentForecastingGene Expression RegulationGlycolysisHumansHydrogen-Ion ConcentrationLymphokines
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5,147
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References
121
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References
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The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated Macrophages
American Journal Of Pathology · 2000 · 1,298 citations
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.
Proceedings of the National Academy of Sciences · 1995 · 6,172 citations
HIF-1alpha is required for solid tumor formation and embryonic vascularization
The EMBO Journal · 1998 · 1,593 citations
Tumor Hypoxia: Definitions and Current Clinical, Biologic, and Molecular Aspects
JNCI Journal of the National Cancer Institute · 2001 · 2,637 citations
Oncogenic alterations of metabolism
Trends in Biochemical Sciences · 1999 · 1,095 citations
HER2 (neu) Signaling Increases the Rate of Hypoxia-Inducible Factor 1α (HIF-1α) Synthesis: Novel Mechanism for HIF-1-Mediated Vascular Endothelial Growth Factor Expression
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