reviewTop 1% cited
Cellular adaptation to hypoxia: O <sub>2</sub> ‐sensing protein hydroxylases, hypoxia‐inducible transcription factors, and O <sub>2</sub> ‐regulated gene expression
The FASEB Journal · 2002 · Vol. 16(10) · pp. 1151–1162
Roland H. Wenger✉(Leipzig University)
Abstract
Although it was known for a long time that oxygen deprivation leads to the transcriptional induction of the gene encoding erythropoietin, the molecular mechanisms behind this process remained enigmatic. The cloning of the hypoxia-inducible factors (HIFs), the finding that HIF-1 regulates the expression of many more genes apart from erythropoietin, and the elucidation of the oxygen-dependent mechanisms degrading the HIF alpha subunits recently led to the spectacular discovery of the molecular principles of oxygen sensing. This review aims to summarize our current knowledge of oxygen-regulated gene expression..
Cancer, Hypoxia, and MetabolismFibroblast Growth Factor ResearchAdipose Tissue and MetabolismGeneTranscription factorGene expressionTranscription (linguistics)Hypoxia (environmental)BiologyErythropoietinCell biologyHypoxia-inducible factorsRegulation of gene expression
MeSH terms
Adaptation, PhysiologicalAnimalsDNA-Binding ProteinsGlucoseHumansMixed Function OxygenasesIronLigasesNuclear ProteinsOxygenTranscription FactorsTranscriptional ActivationCell HypoxiaReceptors, Aryl HydrocarbonTumor Suppressor Proteins
Funding
- Deutsche Forschungsgemeinschaft
Citations
1,122
FWCI
32.33
field-weighted impact
References
187
Percentile
100%
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Citations per year
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References
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The EMBO Journal · 1998 · 1,593 citations
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Journal of Experimental Biology · 2000 · 453 citations
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Molecular and Cellular Biology · 1992 · 2,445 citations
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