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A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

The EMBO Journal · 2012 · Vol. 31(5) · pp. 1095–1108

Carmine Settembre✉(Baylor College of Medicine)Roberto Zoncu(Massachusetts Institute of Technology)Diego L. Medina(Telethon Institute Of Genetics And Medicine)Francesco Vetrini(Baylor College of Medicine)Serkan Erdin(Texas Children's Hospital)SerpilUckac Erdin(Baylor College of Medicine)Tuong Huynh(Neurological Research Institute)Mathieu Ferron(Columbia University)Gérard Karsenty(Columbia University)Michel Vellard(BioMarin (United States))Valeria Facchinetti(The University of Texas MD Anderson Cancer Center)David M. Sabatini(Koch Institute for Integrative Cancer Research At MIT)Andrea Ballabio(Texas Children's Hospital)

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Calcium signaling and nucleotide metabolism Autophagy in Disease and Therapy PI3K/AKT/mTOR signaling in cancerTFEBLysosomemTORC1Cell biologyBiologyAutophagyMechanistic target of rapamycinPI3K/AKT/mTOR pathwayBasic helix-loop-helix leucine zipper transcription factorsTranscription factor

MeSH terms

Mechanistic Target of Rapamycin Complex 1AnimalsCell LineCell NucleusHumansLysosomesMicroscopy, FluorescenceModels, BiologicalProtein BindingProteinsSignal TransductionMice, KnockoutProtein Interaction MappingMultiprotein ComplexesImmunoprecipitation

Funding

Ellison Medical Foundation
March of Dimes Foundation
Jane Coffin Childs Memorial Fund for Medical Research
LAM Foundation
Beyond Batten Disease Foundation
Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
National Institutes of Health

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1,886

FWCI

63.14

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mTOR: a pharmacologic target for autophagy regulation