reviewTop 1% cited

mTOR: from growth signal integration to cancer, diabetes and ageing

Nature Reviews Molecular Cell Biology · 2010 · Vol. 12(1) · pp. 21–35

Roberto Zoncu✉(Whitehead Institute for Biomedical Research)Alejo Efeyan(Massachusetts Institute of Technology)David M. Sabatini(Whitehead Institute for Biomedical Research)

View via DOI Publisher page

PI3K/AKT/mTOR signaling in cancer Fungal Biology and Applications Genetics, Aging, and Longevity in Model OrganismsmTORC1PI3K/AKT/mTOR pathwaymTORC2P70-S6 Kinase 1Nutrient sensingBiologyTOR signalingCell biologyKinaseProtein kinase B

MeSH terms

AgingAnimalsDiabetes MellitusHumansNeoplasmsSignal TransductionGene Expression Regulation, EnzymologicTOR Serine-Threonine Kinases

Citations

3,931

FWCI

131.86

field-weighted impact

References

211

Percentile

100%

vs. same field & year

Citations per year

Cited by

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

The EMBO Journal · 2012 · 1,886 citations

Regulation of autophagy by mTOR-dependent and mTOR-independent pathways: autophagy dysfunction in neurodegenerative diseases and therapeutic application of autophagy enhancers

Biochemical Society Transactions · 2013 · 363 citations

Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks

Biochemical Journal · 2011 · 1,004 citations

The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation

Trends in Biochemical Sciences · 2011 · 1,790 citations

AMP-activated protein kinase—an energy sensor that regulates all aspects of cell function

Genes & Development · 2011 · 1,604 citations

Towards a glutamate hypothesis of depression

Neuropharmacology · 2011 · 1,005 citations

Oxidative stress and autophagy: the clash between damage and metabolic needs

Cell Death and Differentiation · 2014 · 2,147 citations

Frontiers in Immunology · 2018 · 1,234 citations

References

The Forkhead Transcription Factor Foxo1 Regulates Adipocyte Differentiation

Developmental Cell · 2003 · 727 citations

Prolonged Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB

Molecular Cell · 2006 · 2,633 citations

mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

Biochemical Journal · 2008 · 884 citations

A Role for Autophagy in the Extension of Lifespan by Dietary Restriction in C. elegans

PLoS Genetics · 2008 · 758 citations

Ablation in Mice of the mTORC Components raptor, rictor, or mLST8 Reveals that mTORC2 Is Required for Signaling to Akt-FOXO and PKCα, but Not S6K1

Developmental Cell · 2006 · 1,398 citations

Molecular mechanisms of mTOR-mediated translational control

Nature Reviews Molecular Cell Biology · 2009 · 2,525 citations

Regulation of TORC1 by Rag GTPases in nutrient response

Nature Cell Biology · 2008 · 1,317 citations

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

Nature Cell Biology · 2002 · 3,038 citations

Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks

Biochemical Journal · 2011 · 1,004 citations

Citation Network

How this paper connects to the literature. Drag to explore, click any node to open that paper.