review Open AccessTop 1% cited
mTOR at the nexus of nutrition, growth, ageing and disease
Nature Reviews Molecular Cell Biology · 2020 · Vol. 21(4) · pp. 183–203
Grace Y. Liu✉(Broad Institute)David M. Sabatini(Broad Institute)
PI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and CancerPolyamine Metabolism and ApplicationsPI3K/AKT/mTOR pathwayAutophagymTORC2Mechanistic target of rapamycinNeurodegenerationContext (archaeology)mTORC1BiologyCell biologySignalling
MeSH terms
AgingAnimalsAutophagyHumansMetabolic DiseasesNeoplasmsNutritional StatusProtein BiosynthesisSignal TransductionTOR Serine-Threonine Kinases
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References
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
Nature Cell Biology · 2011 · 6,906 citations
Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1
Molecular Cell · 2010 · 1,954 citations
Prolonged Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB
Molecular Cell · 2006 · 2,633 citations
mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)
Biochemical Journal · 2008 · 884 citations
A Role for Autophagy in the Extension of Lifespan by Dietary Restriction in C. elegans
PLoS Genetics · 2008 · 758 citations
Ablation in Mice of the mTORC Components raptor, rictor, or mLST8 Reveals that mTORC2 Is Required for Signaling to Akt-FOXO and PKCα, but Not S6K1
Developmental Cell · 2006 · 1,398 citations
Regulation of TORC1 by Rag GTPases in nutrient response
Nature Cell Biology · 2008 · 1,317 citations
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
Nature Cell Biology · 2002 · 3,038 citations
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