Life Sciences → Biochemistry, Genetics and Molecular Biology → Physiology
Calcium signaling and nucleotide metabolism
This cluster of papers explores the evolution, function, and dysregulation of lysosomal calcium signaling, focusing on the role of two-pore channels, NAADP, TRPML1, and cyclic ADP-ribose in intracellular calcium release and endolysosomal trafficking. It also investigates the implications of these mechanisms in diseases such as mucolipidosis type IV and lysosomal storage disorders.
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Lysosomal Calcium SignalingTwo-pore ChannelsNAADPTRPML1Endolysosomal TraffickingCyclic ADP-RiboseMucolipidosis Type IVIntracellular Calcium ReleaseNicotinic Acid Adenine Dinucleotide PhosphateLysosomal Storage Diseases