review Open AccessTop 1% cited
AMPK: guardian of metabolism and mitochondrial homeostasis
Nature Reviews Molecular Cell Biology · 2017 · Vol. 19(2) · pp. 121–135
Sébastien Herzig✉(Salk Institute for Biological Studies)Reuben J. Shaw(Salk Institute for Biological Studies)
Metabolism, Diabetes, and CancerAutophagy in Disease and TherapyPancreatic function and diabetesAMPKMitophagyCell biologyAutophagyMitochondrionAMP-activated protein kinaseProtein kinase ANutrient sensingBiologyCatabolism
MeSH terms
Adenosine TriphosphatasesAnimalsAutophagyEnergy MetabolismHomeostasisHumansMitochondriaPhosphorylationProtein Serine-Threonine KinasesAMP-Activated Protein Kinases
Citations
3,823
FWCI
70.75
field-weighted impact
References
249
Percentile
100%
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Citations per year
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References
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
Nature Cell Biology · 2011 · 6,906 citations
LKB1 Is the Upstream Kinase in the AMP-Activated Protein Kinase Cascade
Current Biology · 2003 · 1,631 citations
ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase
Nature Cell Biology · 2013 · 1,512 citations
AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-Induced Insulin-Resistant Mice
Cell Metabolism · 2011 · 1,713 citations
Isolation and characterization of autophagy‐defective mutants of <i>Saccharomyces cerevisiae</i>
FEBS Letters · 1993 · 1,727 citations
AMPK regulation of fatty acid metabolism and mitochondrial biogenesis: Implications for obesity
Molecular and Cellular Endocrinology · 2012 · 351 citations
Fatty Acid Trafficking in Starved Cells: Regulation by Lipid Droplet Lipolysis, Autophagy, and Mitochondrial Fusion Dynamics
Developmental Cell · 2015 · 976 citations
Calmodulin-dependent protein kinase kinase-β is an alternative upstream kinase for AMP-activated protein kinase
Cell Metabolism · 2005 · 1,557 citations
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