review Open AccessTop 1% cited

mTOR Signaling in Growth Control and Disease

Cell · 2012 · Vol. 149(2) · pp. 274–293

Mathieu Laplante(Whitehead Institute for Biomedical Research)David M. Sabatini✉(Center for Cancer Research)

PI3K/AKT/mTOR signaling in cancer Metabolism, Diabetes, and Cancer Protein Kinase Regulation and GTPase SignalingPI3K/AKT/mTOR pathwayBiologyNeurodegenerationMechanistic target of rapamycinSignal transductionDiseaseNeuroscienceProtein kinase BCell biologyBioinformatics

MeSH terms

AnimalsHumansMetabolic DiseasesNeoplasmsStem CellsSignal TransductionNeurodegenerative DiseasesTOR Serine-Threonine Kinases

Funding

National Institutes of Health
Canadian Institutes of Health Research

Citations

8,373

FWCI

265.52

field-weighted impact

References

181

Percentile

100%

vs. same field & year

Citations per year

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References

Eaten alive: a history of macroautophagy

Nature Cell Biology · 2010 · 2,075 citations

Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

Molecular Cell · 2010 · 1,954 citations

Prolonged Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB

Molecular Cell · 2006 · 2,633 citations

Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease

Journal of Clinical Investigation · 2005 · 3,421 citations

mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

Biochemical Journal · 2008 · 884 citations

A Role for Autophagy in the Extension of Lifespan by Dietary Restriction in C. elegans

PLoS Genetics · 2008 · 758 citations

Ablation in Mice of the mTORC Components raptor, rictor, or mLST8 Reveals that mTORC2 Is Required for Signaling to Akt-FOXO and PKCα, but Not S6K1

Developmental Cell · 2006 · 1,398 citations

Molecular mechanisms of mTOR-mediated translational control

Nature Reviews Molecular Cell Biology · 2009 · 2,525 citations

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