article Open AccessTop 1% cited
A Small-Molecule Inhibitor of Tgf-β Signaling Replaces Sox2 in Reprogramming by Inducing Nanog
Cell stem cell · 2009 · Vol. 5(5) · pp. 491–503
Justin K. Ichida(Harvard University)Joel Blanchard(Harvard University)Kelvin Lam(Harvard University)Esther Son(Harvard University)Julia Eunyoung Chung(Harvard University)Dieter Egli(Harvard Stem Cell Institute)Kyle M. Loh(Harvard University)Ava C. Carter(Stowers Institute for Medical Research)Francesco Paolo Di Giorgio(Harvard Stem Cell Institute)Kathryn Koszka(Harvard Stem Cell Institute)Danwei Huangfu(Harvard University)Hidenori Akutsu(National Center For Child Health and Development)David R. Liu(Howard Hughes Medical Institute)Lee L. Rubin✉(Harvard Stem Cell Institute)Kevin Eggan✉(Stowers Institute for Medical Research)
Pluripotent Stem Cells ResearchCRISPR and Genetic EngineeringRenal and related cancersReprogrammingSOX2Homeobox protein NANOGBiologyInduced pluripotent stem cellTranscription factorKLF4Cell biologySomatic cellTransgene
MeSH terms
Nanog Homeobox ProteinAnimalsAntibodies, MonoclonalBenzamidesCell LineDioxolesPyrazolesPyridinesTransduction, GeneticSignal TransductionTransforming Growth Factor betaReceptors, Transforming Growth Factor betaHomeodomain ProteinsMiceCell Transdifferentiation
Citations
797
FWCI
33.21
field-weighted impact
References
41
Percentile
100%
vs. same field & year
Citations per year
Cited by
TGFβ signalling in context
Nature Reviews Molecular Cell Biology · 2012 · 3,088 citations
Human iPSC-Based Modeling of Late-Onset Disease via Progerin-Induced Aging
Cell stem cell · 2013 · 755 citations
A Mesenchymal-to-Epithelial Transition Initiates and Is Required for the Nuclear Reprogramming of Mouse Fibroblasts
Cell stem cell · 2010 · 1,142 citations
Functional Genomics Reveals a BMP-Driven Mesenchymal-to-Epithelial Transition in the Initiation of Somatic Cell Reprogramming
Cell stem cell · 2010 · 1,001 citations
References
Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells
Nature Cell Biology · 2007 · 1,246 citations
Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts
Nature Biotechnology · 2007 · 2,767 citations
Generation of Human Induced Pluripotent Stem Cells by Direct Delivery of Reprogramming Proteins
Cell stem cell · 2009 · 1,785 citations
Discovery of a Novel, Potent, and Src Family-selective Tyrosine Kinase Inhibitor
Journal of Biological Chemistry · 1996 · 1,951 citations
Defining Molecular Cornerstones during Fibroblast to iPS Cell Reprogramming in Mouse
Cell stem cell · 2008 · 824 citations
Induction of Pluripotent Stem Cells from Mouse Embryonic Fibroblasts by Oct4 and Klf4 with Small-Molecule Compounds
Cell stem cell · 2008 · 898 citations
Core Transcriptional Regulatory Circuitry in Human Embryonic Stem Cells
Cell · 2005 · 4,462 citations
SB-431542 Is a Potent and Specific Inhibitor of Transforming Growth Factor-β Superfamily Type I Activin Receptor-Like Kinase (ALK) Receptors ALK4, ALK5, and ALK7
Molecular Pharmacology · 2002 · 1,647 citations
Related articles
Reprogramming of Mouse and Human Cells to Pluripotency Using Mature MicroRNAs
Cell stem cell · 2011 · 752 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.