articleTop 1% cited
Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells
Nature Cell Biology · 2007 · Vol. 9(6) · pp. 625–635
Shinji Masui✉(Saitama International Medical Center)Yuhki NakatakeYayoi ToyookaDaisuke Shimosato(Kobe University)Rika YagiKazue TakahashiHitoshi OkochiAkihiko Okuda(Saitama Medical University)Ryo Matoba(National Institutes of Health)Alexei A. Sharov(National Institute on Aging)Minoru S.H. Ko(National Institutes of Health)Hitoshi Niwa(Japan Science and Technology Agency)
Pluripotent Stem Cells ResearchCRISPR and Genetic EngineeringRenal and related cancersSOX2Homeobox protein NANOGInduced pluripotent stem cellEmbryonic stem cellCell biologyBiologyEnhancerStem cellRex1Transcription factor
MeSH terms
Nanog Homeobox ProteinOrganic Cation Transporter 3AnimalsCell DifferentiationCell LineCells, CulturedDNA-Binding ProteinsEnhancer Elements, GeneticMice, Inbred C57BLTranscription FactorsTranscriptional ActivationTrans-ActivatorsUp-RegulationMice, KnockoutHomeodomain Proteins
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References
Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells
Nature Genetics · 2000 · 3,587 citations
Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst
Development · 2005 · 1,133 citations
Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3
Genes & Development · 1998 · 1,530 citations
Phylogeny of the SOX Family of Developmental Transcription Factors Based on Sequence and Structural Indicators
Developmental Biology · 2000 · 962 citations
Core Transcriptional Regulatory Circuitry in Human Embryonic Stem Cells
Cell · 2005 · 4,462 citations
The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells
Nature Genetics · 2006 · 2,442 citations
Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors
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Multipotent cell lineages in early mouse development depend on SOX2 function
Genes & Development · 2003 · 2,368 citations
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