articleTop 1% cited
SB-431542 Is a Potent and Specific Inhibitor of Transforming Growth Factor-β Superfamily Type I Activin Receptor-Like Kinase (ALK) Receptors ALK4, ALK5, and ALK7
Molecular Pharmacology · 2002 · Vol. 62(1) · pp. 65–74
Gareth J. Inman✉(Cancer Research UK)Francisco José Nicolás(GlaxoSmithKline (United States))James F. Callahan(GlaxoSmithKline (United States))John D. Harling(Cancer Research UK)Laramie M. Gaster(GlaxoSmithKline (United Kingdom))Alastair D. Reith(GlaxoSmithKline (United States))Nicholas J. Laping(Cancer Research UK)Caroline S. Hill(Cancer Research UK)
TGF-β signaling in diseasesHeterotopic Ossification and Related ConditionsBone Metabolism and DiseasesSignal transductionActivin receptorCell biologyBiologyKinaseJanus kinase 1ACVR2BActivin type 2 receptorsBMPR2TGF beta signaling pathway
MeSH terms
Receptor, Transforming Growth Factor-beta Type IAnimalsCells, CulturedDNA-Binding ProteinsDrug InteractionsEnzyme ActivationEnzyme InhibitorsHumansOsmotic PressurePhosphorylationProteinsTranscription FactorsTranscription, GeneticSignal TransductionTrans-Activators
Funding
- Cancer Research Institute
- University of Texas Southwestern Medical Center
- Cancer Research UK
Citations
1,647
FWCI
10.73
field-weighted impact
References
44
Percentile
99%
vs. same field & year
Citations per year
Cited by
TGF-β and the Smad Signaling Pathway Support Transcriptomic Reprogramming during Epithelial-Mesenchymal Cell Transition
Molecular Biology of the Cell · 2005 · 587 citations
Targeting senescent cells enhances adipogenesis and metabolic function in old age
eLife · 2015 · 581 citations
Activin/Nodal and FGF pathways cooperate to maintain pluripotency of human embryonic stem cells
Journal of Cell Science · 2005 · 938 citations
TGFβ/activin/nodal signaling is necessary for the maintenance of pluripotency in human embryonic stem cells
Development · 2005 · 883 citations
Stage-Specific Optimization of Activin/Nodal and BMP Signaling Promotes Cardiac Differentiation of Mouse and Human Pluripotent Stem Cell Lines
Cell stem cell · 2011 · 1,171 citations
Targeting TGF-β Mediated SMAD Signaling for the Prevention of Fibrosis
Frontiers in Pharmacology · 2017 · 554 citations
Inhibition of Transforming Growth Factor (TGF)-β1–Induced Extracellular Matrix with a Novel Inhibitor of the TGF-β Type I Receptor Kinase Activity: SB-431542
Molecular Pharmacology · 2002 · 647 citations
SB-505124 Is a Selective Inhibitor of Transforming Growth Factor-β Type I Receptors ALK4, ALK5, and ALK7
Molecular Pharmacology · 2004 · 414 citations
References
Identification of a Novel Inhibitor of Mitogen-activated Protein Kinase Kinase
Journal of Biological Chemistry · 1998 · 3,023 citations
Inhibition of Transforming Growth Factor (TGF)-β1–Induced Extracellular Matrix with a Novel Inhibitor of the TGF-β Type I Receptor Kinase Activity: SB-431542
Molecular Pharmacology · 2002 · 647 citations
NEW EMBO MEMBERS REVIEW: Transcriptional control by the TGF-beta/Smad signaling system
The EMBO Journal · 2000 · 1,960 citations
MKK3- and MKK6-Regulated Gene Expression Is Mediated by the p38 Mitogen-Activated Protein Kinase Signal Transduction Pathway
Molecular and Cellular Biology · 1996 · 1,281 citations
Direct binding of Smad3 and Smad4 to critical TGFbeta -inducible elements in the promoter of human plasminogen activator inhibitor-type 1gene
The EMBO Journal · 1998 · 1,788 citations
Controlling TGF-β signaling
Genes & Development · 2000 · 1,563 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.