articleTop 1% cited

Ubiquitination of hypoxia-inducible factor requires direct binding to the β-domain of the von Hippel–Lindau protein

Nature Cell Biology · 2000 · Vol. 2(7) · pp. 423–427

Michael Ohh✉(Harvard University)Cheol Won Park(Howard Hughes Medical Institute)Mircea Ivan(Brigham and Women's Hospital)Michael A. Hoffman(Harvard University)Tae‐You Kim(Brigham and Women's Hospital)Eric Huang(Brigham and Women's Hospital)Nikola P. Pavletich(Memorial Sloan Kettering Cancer Center)Vincent Chau(Pennsylvania State University)William G. Kaelin(Brigham and Women's Hospital)

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Cancer, Hypoxia, and Metabolism Peroxisome Proliferator-Activated Receptors Lipid metabolism and biosynthesisUbiquitinHypoxia-inducible factorsCell biologyChemistryFunction (biology)BiologyCancer researchGeneBiochemistry

MeSH terms

ElonginCell ExtractsDeferoxamineDNA-Binding ProteinsHeLa CellsHumansLigasesMutationNuclear ProteinsOxygenProtein BindingProtein Processing, Post-TranslationalProteinsTranscription FactorsTransfection

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Cellular adaptation to hypoxia: O <sub>2</sub> ‐sensing protein hydroxylases, hypoxia‐inducible transcription factors, and O <sub>2</sub> ‐regulated gene expression