review Open AccessTop 1% cited

Biology of HIF-1α

Cell Death and Differentiation · 2008 · Vol. 15(4) · pp. 621–627

Alexander Weidemann✉(University of California, San Diego)Randall S. Johnson(University of California, Los Angeles)

Cancer, Hypoxia, and Metabolism High Altitude and Hypoxia Adipose Tissue and MetabolismOrganismHypoxia (environmental)BiologyRegulatorHomeostasisCell biologyHypoxia-inducible factorsOxygenPhysiologyChemistry

MeSH terms

Adaptation, PhysiologicalAnimalsHypoxiaHumansHydroxylationNeoplasmsProtein Processing, Post-TranslationalSignal TransductionCell HypoxiaMice, KnockoutNeovascularization, PhysiologicProtein IsoformsMiceHypoxia-Inducible Factor 1, alpha Subunit

Citations

914

FWCI

16.65

field-weighted impact

References

Percentile

99%

vs. same field & year

Citations per year

Cited by

STAT3 Target Genes Relevant to Human Cancers

Cancers · 2014 · 523 citations

Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes

Trends in Biochemical Sciences · 2010 · 974 citations

References

Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension

American Journal of Physiology-Cell Physiology · 1996 · 1,209 citations

ISOLATION OF A TUMOR FACTOR RESPONSIBLE FOR ANGIOGENESIS

The Journal of Experimental Medicine · 1971 · 1,661 citations

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

Genes & Development · 2002 · 1,520 citations

HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

Cell Metabolism · 2006 · 2,210 citations

HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia

Cell Metabolism · 2006 · 3,827 citations

The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated Macrophages

American Journal Of Pathology · 2000 · 1,298 citations

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

Proceedings of the National Academy of Sciences · 1995 · 6,172 citations

Cellular and developmental control of O<sub>2</sub> homeostasis by hypoxia-inducible factor 1α

Genes & Development · 1998 · 2,467 citations

Citation Network

How this paper connects to the literature. Drag to explore, click any node to open that paper.