article Open AccessTop 1% cited
The NALP3 inflammasome is involved in the innate immune response to amyloid-β
Nature Immunology · 2008 · Vol. 9(8) · pp. 857–865
Annett Halle✉(University of Massachusetts Chan Medical School)Veit Hornung(University of Massachusetts Chan Medical School)Gabor C. Petzold(Harvard University)Cameron R. Stewart(Boston University)Brian G. Monks(University of Massachusetts Chan Medical School)Thomas Reinheckel(University of Freiburg)Katherine A. Fitzgerald(University of Massachusetts Chan Medical School)Eicke Latz(University of Massachusetts Chan Medical School)Kathryn J. Moore(Harvard University)Douglas T. Golenbock(University of Massachusetts Chan Medical School)
Inflammasome and immune disordersGalectins and Cancer BiologyCalcium signaling and nucleotide metabolismInflammasomeNALP3Proinflammatory cytokineAmyloid betaCaspase 1MicrogliaInflammationAIM2Innate immune systemBETA (programming language)
MeSH terms
NLR Family, Pyrin Domain-Containing 3 ProteinAlzheimer DiseaseCarrier ProteinsImmunity, InnateInflammationAmyloid beta-PeptidesInflammation Mediators
Citations
2,375
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References
Inflammasome Components NALP 1 and 3 Show Distinct but Separate Expression Profiles in Human Tissues Suggesting a Site-specific Role in the Inflammatory Response
Journal of Histochemistry & Cytochemistry · 2006 · 529 citations
Interleukin-1β and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer's and de novo Parkinson's disease patients
Neuroscience Letters · 1995 · 794 citations
The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation
Cell Death and Differentiation · 2007 · 1,018 citations
NALP3 Forms an IL-1β-Processing Inflammasome with Increased Activity in Muckle-Wells Autoinflammatory Disorder
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