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NALP3 Forms an IL-1β-Processing Inflammasome with Increased Activity in Muckle-Wells Autoinflammatory Disorder

Immunity · 2004 · Vol. 20(3) · pp. 319–325
Laetitia AgostiniFabio MartinonKimberly BurnsMichael McDermottPhilip N. HawkinsJürg Tschopp
Inflammasome and immune disordersIon Channels and ReceptorsIL-33, ST2, and ILC PathwaysNALP3InflammasomeCaspase 1AIM2Proinflammatory cytokineBiologyMedicineImmunologyInflammation

MeSH terms

NLR Family, Pyrin Domain-Containing 3 ProteinAutoimmune DiseasesCarrier ProteinsCell LineCells, CulturedCytoskeletal ProteinsHumansInflammationInterleukin-1MacrophagesMutationNeoplasm ProteinsProtein PrecursorsProtein Structure, TertiaryCaspase 1
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NALP3 Forms an IL-1β-Processing Inflammasome with Increased Activity in Muckle-Wells Autoinflammatory Disorder · Scinovex