review Open AccessTop 10% cited
FXR signaling in the enterohepatic system
Molecular and Cellular Endocrinology · 2012 · Vol. 368(1-2) · pp. 17–29
Tsutomu Matsubara✉(Center for Cancer Research)Fei Li(National Cancer Institute)Frank J. Gonzalez(National Cancer Institute)
Drug Transport and Resistance MechanismsPediatric Hepatobiliary Diseases and TreatmentsNuclear Receptors and SignalingFarnesoid X receptorCYP8B1Lithocholic acidBile acidG protein-coupled bile acid receptorEnterohepatic circulationPregnane X receptorCholesterol 7 alpha-hydroxylaseChenodeoxycholic acidCholic acid
MeSH terms
Receptor, Farnesoid X-ActivatedAnimalsBile Acids and SaltsBiological TransportHomeostasisHumansIntestine, SmallLigandsLiverNeoplasmsXenobioticsSignal TransductionReceptors, Cytoplasmic and Nuclear
Citations
374
FWCI
10.28
field-weighted impact
References
153
Percentile
99%
vs. same field & year
Citations per year
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References
Endogenous Bile Acids Are Ligands for the Nuclear Receptor FXR/BAR
Molecular Cell · 1999 · 1,608 citations
A Regulatory Cascade of the Nuclear Receptors FXR, SHP-1, and LRH-1 Represses Bile Acid Biosynthesis
Molecular Cell · 2000 · 1,884 citations
Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis
Cell Metabolism · 2005 · 1,777 citations
6α-Ethyl-Chenodeoxycholic Acid (6-ECDCA), a Potent and Selective FXR Agonist Endowed with Anticholestatic Activity
Journal of Medicinal Chemistry · 2002 · 725 citations
Molecular Basis for Feedback Regulation of Bile Acid Synthesis by Nuclear Receptors
Molecular Cell · 2000 · 1,462 citations
Bile acids: regulation of synthesis
Journal of Lipid Research · 2009 · 1,598 citations
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FXR signaling in the enterohepatic system
Molecular and Cellular Endocrinology · 2012 · 374 citations
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