article Open AccessTop 1% cited
Molecular Basis for Feedback Regulation of Bile Acid Synthesis by Nuclear Receptors
Molecular Cell · 2000 · Vol. 6(3) · pp. 507–515
Timothy T. Lu(The University of Texas Southwestern Medical Center)Makoto Makishima(Howard Hughes Medical Institute)Joyce J. Repa(Howard Hughes Medical Institute)Kristina Schoonjans(Centre National de la Recherche Scientifique)Thomas A. Kerr(The University of Texas Southwestern Medical Center)Johan Auwerx(Inserm)David J. Mangelsdorf✉(Howard Hughes Medical Institute)
Drug Transport and Resistance MechanismsCholesterol and Lipid MetabolismPeroxisome Proliferator-Activated ReceptorsCholesterol 7 alpha-hydroxylaseBiologyPsychological repressionNuclear receptorRepressorLiver receptor homolog-1Small heterodimer partnerCatabolismActivator (genetics)Transcription factor
MeSH terms
Liver X ReceptorsReceptor, Farnesoid X-ActivatedAnimalsBile Acids and SaltsCells, CulturedCholesterolCholesterol 7-alpha-HydroxylaseDNA-Binding ProteinsFeedbackHomeostasisHumansKidneyPromoter Regions, GeneticRepressor ProteinsTranscription Factors
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1,462
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38
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References
Endogenous Bile Acids Are Ligands for the Nuclear Receptor FXR/BAR
Molecular Cell · 1999 · 1,608 citations
A Regulatory Cascade of the Nuclear Receptors FXR, SHP-1, and LRH-1 Represses Bile Acid Biosynthesis
Molecular Cell · 2000 · 1,884 citations
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