article Open AccessTop 1% cited
A Regulatory Cascade of the Nuclear Receptors FXR, SHP-1, and LRH-1 Represses Bile Acid Biosynthesis
Molecular Cell · 2000 · Vol. 6(3) · pp. 517–526
Bryan Goodwin(Research Triangle Park Foundation)Stacey A. Jones(Research Triangle Park Foundation)Roger R. Price(Research Triangle Park Foundation)Michael A. Watson(Research Triangle Park Foundation)David D. McKee(Research Triangle Park Foundation)Linda B. Moore(Research Triangle Park Foundation)Cristin M. Galardi(Research Triangle Park Foundation)Joan G. Wilson(Research Triangle Park Foundation)Michael C. Lewis(Research Triangle Park Foundation)Matthew E. Roth(Sepragen Corporation (United States))Patrick Maloney(Research Triangle Park Foundation)Timothy M. Willson(Research Triangle Park Foundation)Steven A. Kliewer✉(Research Triangle Park Foundation)
Drug Transport and Resistance MechanismsCholesterol and Lipid MetabolismPharmacogenetics and Drug MetabolismFarnesoid X receptorSmall heterodimer partnerCholesterol 7 alpha-hydroxylaseG protein-coupled bile acid receptorBiologyBile acidNuclear receptorLiver receptor homolog-1CYP8B1Psychological repression
MeSH terms
Receptor, Farnesoid X-ActivatedAnimalsBile Acids and SaltsCells, CulturedCholesterol 7-alpha-HydroxylaseDNA-Binding ProteinsHumansMalePromoter Regions, GeneticRats, Inbred F344Repressor ProteinsRNA, MessengerTranscription FactorsTransfectionBlotting, Northern
Citations
1,884
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53
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100%
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References
Endogenous Bile Acids Are Ligands for the Nuclear Receptor FXR/BAR
Molecular Cell · 1999 · 1,608 citations
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