article Open AccessTop 1% cited
Immunohistochemical and Clinical Characterization of the Basal-Like Subtype of Invasive Breast Carcinoma
Clinical Cancer Research · 2004 · Vol. 10(16) · pp. 5367–5374
Torsten O. Nielsen✉(BC Cancer Agency)Forrest D. Hsu(BC Cancer Agency)Kristin C. JensenMaggie C.U. Cheang(BC Cancer Agency)Gamze Karaca(UNC Lineberger Comprehensive Cancer Center)Zhiyuan Hu(UNC Lineberger Comprehensive Cancer Center)Tina Hernandez‐Boussard(Stanford University)Chad Livasy(UNC Lineberger Comprehensive Cancer Center)Dave Cowan(University of North Carolina at Chapel Hill)Lynn G. Dressler(Segeberger Kliniken)Lars A. Akslen(Haukeland University Hospital)Joseph Ragaz(Royal Victoria Hospital)Allen M. GownC. Blake Gilks(BC Cancer Agency)Matt van de RijnCharles M. Perou(Segeberger Kliniken)
Abstract
A panel of four antibodies (ER, HER1, HER2, and cytokeratin 5/6) can accurately identify basal-like tumors using standard available clinical tools and shows high specificity. These studies show that many basal-like tumors express HER1, which suggests candidate drugs for evaluation in these patients.
Breast Cancer Treatment StudiesHER2/EGFR in Cancer ResearchCancer and Skin LesionsCytokeratinTissue microarrayImmunohistochemistryBasal (medicine)Breast cancerPathologyBreast carcinomaEstrogen receptorBiologyEstrogen
MeSH terms
Breast NeoplasmsFemaleHumansImmunohistochemistryKeratinsNeoplasm InvasivenessReceptors, EstrogenBiomarkers, TumorSurvival AnalysisNeoplasms, Basal CellErb-b2 Receptor Tyrosine KinasesReceptor, ErbB-2Oligonucleotide Array Sequence Analysis
Funding
- Michael Smith Health Research BC
- University of North Carolina at Chapel Hill
- National Cancer Institute
Citations
2,652
FWCI
44.30
field-weighted impact
References
27
Percentile
100%
vs. same field & year
Citations per year
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