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Breast cancer stem cell markers CD44, CD24 and ALDH1: expression distribution within intrinsic molecular subtype

Journal of Clinical Pathology · 2011 · Vol. 64(11) · pp. 937–946

Sara Ricardo(Universidade do Porto)André Filipe Vieira(Universidade do Porto)Renê Gerhard(Universidade do Porto)Dina Leitão(Universidade do Porto)Regina Pinto(Universidade do Porto)José Cameselle‐Teijeiro(University Hospital Complex Of Vigo)Fernanda Milanezi(Universidade do Porto)Fernando Schmitt(Universidade do Porto)Joana Paredes✉

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Abstract

CD44(+)CD24(-/low) and ALDH1(+) phenotypes seem to identify CSC with distinct levels of differentiation. It seems that the paramount method and biomarkers that identify breast CSC within the distinct molecular subtypes need to be better explored, because it is pivotal to translate the CSC concept to clinical practice. In the future, the recognition of reliable markers to distinguish the CSC pool in each molecular subtype will be decisive for the development of specific target therapies.

Cancer Cells and Metastasis Cancer Genomics and Diagnostics Metastasis and carcinoma case studiesCD44CD24Cancer stem cellBreast cancerCancer researchCancerBiologyPathologyCA15-3Stem cell

MeSH terms

Aldehyde Dehydrogenase 1 FamilyAdultAgedAged, 80 and overBreast NeoplasmsFemaleHumansImmunohistochemistryIsoenzymesMiddle AgedPhenotypeBiomarkers, TumorNeoplastic Stem CellsDisease-Free SurvivalHyaluronan Receptors