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Tissue microarrays for high-throughput molecular profiling of tumor specimens

Nature Medicine · 1998 · Vol. 4(7) · pp. 844–847

Juha Kononen✉(Cancer Genetics (United States))Lukas Bubendorf(University of Basel)Anne Kallionimeni(National Human Genome Research Institute)Maarit Bärlund(Tampere University)Peter Schraml(University of Basel)Stephen B. LeightonJ. Torhorst(University of Basel)Michael J. Mihatsch(University of Basel)Guido Sauter(University of Basel)Olli-P. Kallionimeni(National Institutes of Health)

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Gene expression and cancer classification Genomic variations and chromosomal abnormalities Molecular Biology Techniques and ApplicationsDNA microarrayBiologyGene expression profilingTissue microarrayMicroarrayBreast cancerComplementary DNAGeneComputational biologyGene expression

MeSH terms

AnimalsBreast NeoplasmsFemaleGenetic TechniquesHumansImmunoenzyme TechniquesRabbitsReceptors, EstrogenBiomarkers, TumorRetroviridae Proteins, OncogenicTumor Suppressor Protein p53Proto-Oncogene Proteins c-mycIn Situ Hybridization, FluorescenceReceptor, ErbB-2Erb-b2 Receptor Tyrosine Kinases

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Molecular Classification of Cancer: Class Discovery and Class Prediction by Gene Expression Monitoring