reviewTop 1% cited
IL-6 as a keystone cytokine in health and disease
Nature Immunology · 2015 · Vol. 16(5) · pp. 448–457
Christopher A. Hunter✉(University of Pennsylvania)Simon A. Jones(Cardiff University)
Cytokine Signaling Pathways and InteractionsPsoriasis: Treatment and PathogenesisWhipple's Disease and InterleukinsAcquired immune systemContext (archaeology)ImmunologyImmunityDiseaseImmune systemInnate immune systemCytokineInterleukin 15Intervention (counseling)
MeSH terms
Interleukin-6 InhibitorsAnimalsB-LymphocytesDrug Evaluation, PreclinicalHomeostasisHumansImmunity, InnateImmunotherapyPsoriasisSpondylitis, AnkylosingInflammatory Bowel DiseasesSignal TransductionInterleukin-6Antibodies, BlockingReceptors, Interleukin-6
Citations
2,422
FWCI
77.16
field-weighted impact
References
187
Percentile
100%
vs. same field & year
Citations per year
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References
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European Journal of Biochemistry · 2001 · 643 citations
Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17–producing human T helper cells
Nature Immunology · 2007 · 1,798 citations
IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
Nature Immunology · 2007 · 2,108 citations
IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated Cancer
Cancer Cell · 2009 · 2,090 citations
Principles of interleukin (IL)-6-type cytokine signalling and its regulation
Biochemical Journal · 2003 · 3,217 citations
The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis.
Journal of Clinical Investigation · 1998 · 2,239 citations
TGF-β and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain TH-17 cell–mediated pathology
Nature Immunology · 2007 · 1,489 citations
Interleukin 17–producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
Nature Immunology · 2005 · 4,662 citations
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