The immunobiology of cancer: Review

Abstract

The cancerous tumor arises as a result of transformations in the living cell that lead to its division and abnormal reproduction, these shifts include some changes on the surface of the cell, making it different from the first cell. The occurrence of any immune activity against cancerous tumors depends on the appearance of antigens on the surface of the tumor tissue that are not found on the surface of the normal similar tissue, and the first indications of such activity were reflected in the Grom experiments in 1913 AD when mice used internal reproduction (labred mice), where these experiments proved that tumors induced by chemical elements are rejected immune if they are transplanted in the same mice again, and the tumor does not grow, which indicates the immunity of mice against these tumors, This study aims to identify how tumor immunity occurs, identify the immune relationship between the tumor and the host, and use this knowledge for prevention, diagnosis and treatment purposes.