article Open AccessTop 1% cited
IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated Cancer
Cancer Cell · 2009 · Vol. 15(2) · pp. 103–113
Sergei I. Grivennikov✉(University of California, San Diego)Eliad Karin(University of California, San Diego)Janoš Terzić(University of Split)Daniel Mucida(La Jolla Institute for Immunology)Guann‐Yi Yu(University of California, San Diego)Sivakumar Vallabhapurapu(University of California, San Diego)Jürgen Scheller(Kiel University)Stefan Rose‐John(Kiel University)Hilde Cheroutre(La Jolla Institute for Immunology)Lars Eckmann(University of California, San Diego)Michael Karin(University of California, San Diego)
Cytokine Signaling Pathways and InteractionsNF-κB Signaling PathwaysInflammatory Bowel DiseaseCarcinogenesisCancer researchSTAT3Proinflammatory cytokineBiologyCytokineLamina propriaColitisImmunologyInflammatory bowel disease
MeSH terms
AnimalsBone Marrow CellsCell SurvivalColitis, UlcerativeEpithelial CellsGene Expression RegulationHumansIntestinal MucosaMice, Inbred C57BLNeoplasmsTumor Necrosis Factor-alphaSignal TransductionInterleukin-6NF-kappa BMice, Knockout
Funding
- National Institutes of Health
Citations
2,090
FWCI
57.29
field-weighted impact
References
73
Percentile
100%
vs. same field & year
Citations per year
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References
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Nature · 2002 · 14,998 citations
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European Journal of Cancer · 2005 · 967 citations
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Nature reviews. Immunology · 2005 · 3,013 citations
Smoldering and polarized inflammation in the initiation and promotion of malignant disease
Cancer Cell · 2005 · 1,757 citations
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Gut · 2001 · 2,916 citations
TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells
Immunity · 2006 · 3,566 citations
A cytokine-mediated link between innate immunity, inflammation, and cancer
Journal of Clinical Investigation · 2007 · 1,906 citations
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