article Open AccessTop 1% cited
IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases
The EMBO Journal · 1998 · Vol. 17(8) · pp. 2215–2223
Quinn L. Deveraux✉(Sanford Burnham Prebys Medical Discovery Institute)
Cell death mechanisms and regulationPhagocytosis and Immune RegulationRNA Interference and Gene DeliveryXIAPCaspaseBiologyCell biologyCytochrome cProteasesInhibitor of apoptosisApoptosisIntrinsic apoptosisInhibitor of apoptosis domain
MeSH terms
Cell ExtractsCell Line, TransformedCysteine EndopeptidasesCytochrome c GroupCytosolEnzyme ActivationEnzyme PrecursorsHumansProtein Processing, Post-TranslationalProteinsRecombinant Fusion ProteinsTumor Cells, CulturedCysteine Proteinase InhibitorsApoptosisCaspases
Funding
- U.S. Department of Defense
- National Institutes of Health
Citations
1,385
FWCI
33.97
field-weighted impact
References
53
Percentile
100%
vs. same field & year
Citations per year
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References
A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma
Nature Medicine · 1997 · 3,196 citations
Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization
The EMBO Journal · 1998 · 1,231 citations
Spectroscopic Determination of Tryptophan and Tyrosine in Proteins<sup>*</sup>
Biochemistry · 1967 · 3,438 citations
Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade
Cell · 1997 · 7,227 citations
The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases
The EMBO Journal · 1997 · 1,297 citations
Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c
Cell · 1996 · 5,154 citations
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