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The Coagulopathy of Trauma: A Review of Mechanisms
The Journal of Trauma: Injury, Infection, and Critical Care · 2008 · Vol. 65(4) · pp. 748–754
John R. Hess✉(University of Maryland, Baltimore)Karim BrohiRichard P. DuttonCarl J. HauserJohn B. HolcombYoram KlugerKevin Mackway‐JonesMichael ParrSandro RizoliTetsuo YukiokaDavid B. HoytBertil Bouillon
Abstract
There is limited understanding of the mechanisms by which tissue trauma, shock, and inflammation initiate trauma coagulopathy. Acute Coagulopathy of Trauma-Shock should be considered distinct from disseminated intravascular coagulation as described in other conditions. Rapid diagnosis and directed interventions are important areas for future research.
Trauma, Hemostasis, Coagulopathy, ResuscitationTrauma and Emergency Care StudiesMuscle and Compartmental DisordersCoagulopathyMedicineIntensive care medicineDisseminated intravascular coagulationShock (circulatory)Traumatic ShockHypothermiaAnesthesiaSurgeryInternal medicine
MeSH terms
Blood Coagulation DisordersBlood Coagulation TestsBlood TransfusionFemaleHumansMaleMultiple TraumaPrognosisWounds and InjuriesInjury Severity ScoreCritical IllnessRisk Assessment
Citations
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The Journal of Trauma: Injury, Infection, and Critical Care · 2003 · 471 citations
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The Journal of Trauma: Injury, Infection, and Critical Care · 2006 · 447 citations
Acute Coagulopathy of Trauma: Hypoperfusion Induces Systemic Anticoagulation and Hyperfibrinolysis
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