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Two‐year seizure reduction in adults with medically intractable partial onset epilepsy treated with responsive neurostimulation: Final results of the RNS System Pivotal trial
Epilepsia · 2014 · Vol. 55(3) · pp. 432–441
Christianne HeckDavid King‐StephensAndrew MasseyDileep NairBarbara C. JobstGregory L. BarkleyVicenta SalanovaAndrew J. Cole(Massachusetts General Hospital)Michael C. SmithRyder P. GwinnChristopher SkidmorePaul C. Van NessGregory K. BergeyYong D. ParkIan MillerEric B. GellerPaul RuteckiRichard S. ZimmermanDavid SpencerAlica M. GoldmanJonathan Edwards(Medical University of South Carolina)James W. LeiphartRobert E. WharenJames FesslerNathan B. Fountain(University of Virginia)Gregory A. WorrellRobert E. GrossStephan EisenschenkRobert B. DuckrowLawrence J. HirschCarl W. BazilCormac A. O’Donovan(Wake Forest University)Felice T. SunTracy A. CourtneyCairn G. SealeMartha J. Morrell✉
Abstract
Responsive stimulation to the seizure focus reduced the frequency of partial-onset seizures acutely, showed improving seizure reduction over time, was well tolerated, and was acceptably safe. The RNS System provides an additional treatment option for patients with medically intractable partial-onset seizures.
Neurological disorders and treatmentsNeuroscience and Neural EngineeringEpilepsy research and treatmentEpilepsyAdverse effectMedicineNeurostimulationRandomized controlled trialStimulationAnesthesiaSeizure typesDeep brain stimulationClinical endpoint
MeSH terms
AdolescentAdultAgedDouble-Blind MethodElectric Stimulation TherapyEpilepsies, PartialFemaleFollow-Up StudiesHumansMaleMiddle AgedQuality of LifeTime FactorsTreatment OutcomeYoung Adult
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632
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49
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