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Electrical stimulation of the anterior nucleus of thalamus for treatment of refractory epilepsy

Epilepsia · 2010 · Vol. 51(5) · pp. 899–908

Robert S. Fisher✉(Stanford University)Vicenta SalanovaThomas C. WittRobert M. WorthThomas R. Henry(Emory University)Robert E. Gross(Emory University)Kalarickal J. OommenIvan OsorioJules M. NazzaroDouglas LabarMichael G. KaplittMichael R. Sperling(Thomas Jefferson University)Evan Sandok(Marshfield Clinic)John H. Neal(Marshfield Clinic)Adrian HandforthJohn M. SternAntonio A. F. DeSallesSteve Chung(Barrow Neurological Institute)Andrew G. Shetter(Barrow Neurological Institute)Donna BergenRoy A.E. BakayJaimie M. Henderson(Stanford University)Jacqueline A. French(University of Pennsylvania)Gordon H. Baltuch(University of Pennsylvania)William E. RosenfeldAndrew YoukilisWilliam J. MarksPaul A. GarciaN. M. BarbaroNathan B. Fountain(University of Virginia)Carl W. Bazil(Columbia University)Robert Goodman(Columbia University)Guy M. McKhann(Columbia University)K.B. KrishnamurthySteven PapavassiliouCharles M. Epstein(Emory University)John R. Pollard(University of Pennsylvania)Lisa TonderJoan GrebinRobert J. CoffeyNina M. Gravesthe SANTE Study Group

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Abstract

Bilateral stimulation of the anterior nuclei of the thalamus reduces seizures. Benefit persisted for 2 years of study. Complication rates were modest. Deep brain stimulation of the anterior thalamus is useful for some people with medically refractory partial and secondarily generalized seizures.

Neurological disorders and treatments Neuroscience and Neural Engineering EEG and Brain-Computer InterfacesThalamusStimulationEpilepsyDeep brain stimulationAnesthesiaMedicineAdverse effectThalamic stimulatorElectroencephalographyNeurological disorder

MeSH terms

AdultDepressionDouble-Blind MethodElectric Stimulation TherapyEpilepsyEpilepsies, PartialFemaleFollow-Up StudiesHumansFunctional LateralityLongitudinal StudiesMaleMemory DisordersTreatment OutcomeAnterior Thalamic Nuclei