articleTop 1% cited

Efficacy and Safety of Oral Lacosamide as Adjunctive Therapy in Adults with Partial‐Onset Seizures

Epilepsia · 2007 · Vol. 48(7) · pp. 1308–1317

Elinor Ben‐Menachem✉(University of Gothenburg)Victor Biton(Arkansas Cardiology)Dalius Jatužis(Vilnius University)Bassel Abou‐Khalil(Vanderbilt University)Pamela DotyG. David Rudd

View via DOI Publisher page

Abstract

In this trial, adjunctive lacosamide significantly reduced seizure frequency in patients with uncontrolled partial-onset seizures. Along with favorable pharmacokinetic and tolerability profiles, these results support further development of lacosamide as an AED.

Epilepsy research and treatment Pharmacological Effects and Toxicity Studies Neuroscience and Neuropharmacology ResearchLacosamideMedicinePlaceboAnesthesiaAdverse effectAdjunctive treatmentRandomized controlled trialEpilepsyInternal medicinePsychiatry

MeSH terms

LacosamideAcetamidesAdministration, OralAnticonvulsantsAtaxiaDizzinessDouble-Blind MethodDrug Administration ScheduleDrug Therapy, CombinationEpilepsies, PartialHumansNauseaPlacebosTreatment Outcome

Citations

478

FWCI

13.45

field-weighted impact

References

Percentile

99%

vs. same field & year

Citations per year

Cited by

Two‐year seizure reduction in adults with medically intractable partial onset epilepsy treated with responsive neurostimulation: Final results of the RNS System Pivotal trial

Epilepsia · 2014 · 632 citations

Citation Network

How this paper connects to the literature. Drag to explore, click any node to open that paper.