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Importance of P-glycoprotein at blood–tissue barriers

Trends in Pharmacological Sciences · 2004 · Vol. 25(8) · pp. 423–429
Martin F. Fromm
Drug Transport and Resistance MechanismsPharmacological Effects and Toxicity StudiesPediatric Hepatobiliary Diseases and TreatmentsP-glycoproteinGlycoproteinPlacentaEffluxAbcg2Excretory systemTransporterXenobioticATP-binding cassette transporterBiology

MeSH terms

AnimalsBlood-Brain BarrierBlood-Testis BarrierPharmaceutical PreparationsHumansIntestinal MucosaKidneyLiverPharmacokineticsPlacentaATP Binding Cassette Transporter, Subfamily B, Member 1

Funding

  • Deutsche Forschungsgemeinschaft
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References
The multidrug resistance protein family
Biochimica et Biophysica Acta (BBA) - Biomembranes · 1999 · 650 citations
Multidrug resistance in cancer: role of ATP–dependent transporters
Nature reviews. Cancer · 2002 · 5,468 citations
A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants
Biochimica et Biophysica Acta (BBA) - Biomembranes · 1976 · 3,268 citations
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