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Pharmacokinetic interaction of digoxin with an herbal extract from St John's wort (Hypericum perforatum)*1

Clinical Pharmacology & Therapeutics · 1999 · Vol. 66(4) · pp. 338–345

Andreas Johne✉(Charité - Universitätsmedizin Berlin)

Abstract

As with grapefruit juice, a food product, physicians should also be aware of potential drug-herb interactions. The interaction of St John's wort extract with digoxin kinetics was time dependent. The mechanism involved may be induction of the P-glycoprotein drug transporter.

Natural Compound Pharmacology Studies Ion Transport and Channel Regulation Schizophrenia research and treatmentHypericum perforatumDigoxinPharmacokineticsHypericumCmaxPharmacologyPlaceboMedicineDrug interactionTraditional medicine

MeSH terms

AdultAnalysis of VarianceAnti-Arrhythmia AgentsAntidepressive AgentsCardiotonic AgentsDigoxinDrug Administration ScheduleFemaleHumansMalePhytotherapyPlants, MedicinalReference ValuesTime FactorsSingle-Blind Method

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588

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74.92

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Herb-Drug Interactions